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EMAP-II

CAT: 0209-100-010-L20Size: 20 µgDry Ice: NoHazardous: No
CAT#:0209-100-010-L20Size:20 µg
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Description
EMAP-II also called SCYE1 is a tumor derived cytokine that plays a role in a wide variety of activities on endothelial cells, monocytes and neutrophils. EMAP-II inhibits endothelial cell proliferation, vasculogenesis, neovessel formation, and can induce apoptosis. It is also chemotactic towards neutrophils and monocytes and induces myeloperoxidase activity from neutrophils. EMAP-II clinical value is inhibiting angiogenesis of vascular beds and suppressing the growth of primary and secondary tumors with no affect to normal tissues. SCYE1is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this SCYE1 renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. EMAP-2 plays a role in in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells.
Synonyms
AIMP1; p43; HLD3; EMAP2; SCYE1; EMAPII
NCBI Gene ID
9255
UniProt
Q12904
Accession Number
NP_004748
Accession Number mRNA
NM_004757
Chromosomal Location
4q24
Reactivity
Human
Cross Reactivity
Human
Sequence
SKPIDVSRLD LRIGCIITAR KHPDADSLYV EEVDVGEIAP RTVVSGLVNH VPLEQM QNRM VILLCNLKPA KMRGVLSQAM VMCASSPEKI EILAPPNGSV PGDRITFDAF PGEPDKELNP KKKIWEQIQP DLHTNDECVA TYKGVPFEVK GKGVCRAQTM SNSGIK
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by the apoptotic effect on MCF-7 cells using a concentration of 20-30 ng/ml.
Length
166
Form
Lyophilized
Molecular Weight
18.3 kDa
Host or Source
E. coli

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