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LIMP-II

CAT: 0209-103-M428Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-103-M428Size:100 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lysosomes are intracytoplasmic organelles that are found within leukocytes (granulocytes, neutrophils, basophils and eosinophils) and function as storage granules for small particles. Lysosomes actively support subcellular protein degradation mechanisms through fusion with cellular organelles such as phagocytic vacuoles and the plasma membrane. Lysosome fusion to the plasma membrane, known as exocytosis, releases the contents of the vesicle into the extracellular environment. The lysosomal integral membrane proteins I–III, known as LIMP-I, LIMP-II and LIMP-III, localize from the trans-Golgi network to lysosomes via an AP-3-dependent pathway that may involve AP-1 and Clathrin. LIMP I-III are protein markers for the lysosome organelle. These markers are exceptionally useful for microscopy studies, cellular fractionation validation and studies pertaining to protein trafficking through the secretory pathway.
Synonyms
Scarb2; LGP85; Cd36l2; LIMP-2; MLGP85; 9330185J12Rik
NCBI Gene ID
12492
UniProt
O35114
Accession Number
NP_031670.1
Accession Number mRNA
NM_007644.3
Chromosomal Location
5; 5 E3
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Recombinant mouse LIMP-II
Clone
(#1K53)
Applications
WB
Purification Method
Protein A/G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG1

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