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BMP-6

CAT: 0209-100-378-L1000Size: 2x 500 µgDry Ice: NoHazardous: No
CAT#:0209-100-378-L1000Size:2x 500 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. Increasing evidence indicates that BMP-Smad signaling has a tumor suppressing activity and that BMPs can inhibit tumor growth. BMP-6 is abnormally expressed in breast cancer cell lines; however, its function in promoting breast cancer development is unknown. Recombinant human BMP-6 is a 26.2 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.
Synonyms
BMP6; VGR; VGR1
NCBI Gene ID
654
UniProt
P22004
Accession Number
NP_001709
Accession Number mRNA
NM_001718
Chromosomal Location
6p24-p23
Reactivity
Human
Cross Reactivity
Human
Sequence
VSSASDYNSS ELKTACRKHE LYVSFQDLGW QDWIIAPKGY AANYCDGECS FPLNAHMNAT NHAIVQTLVH LMNPEYVPKP CCAPTKLNAI SVLYFDDNSN VILKKYRNMV VRACGCH
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
95% by SDS-PAGE & HPLC analysis
Bioactivity
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 this effect is 0.03-0.06 μg/ml.
Length
117
Form
Lyophilized
Molecular Weight
26.2 kDa
Host or Source
HEK293 cells

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