BMP-4

• Description :

  Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Recombinant human BMP-4, expressed in HeLa cells, is a 31-36 kDa homodimeric glycoprotein.

• Synonyms :

  BMP4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6

• NCBI Gene ID :

  652

• UniProt :

  P12644

• Accession Number :

  NP_001193

• Accession Number mRNA :

  NM_001202

• Chromosomal Location :

  14q22-q23

• Reactivity :

  Human

• Cross Reactivity :

  Human, Mouse, Rat

• Sequence :

  SPKHHSQRAR KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAI VQT LVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR.

• Purity :

  >95% by SDS-PAGE

• Bioactivity :

  The ED50, as calculated by Alkaline phosphatase activity induced in ATDC-5 cells is 15ng/ml corresponding to a specific activity which is 6.7 x 10^4 units/mg.

• Length :

  116

• Form :

  Lyophilized

• Buffer :

  2XS PBS + 6% EtOH

• Reconstitution :

  2XS PBS + 6% EtOH

• Molecular Weight :

  26,2 kDa

• Host or Source :

  CHO cells