BAFF receptor, soluble

CAT: 0209-S01-038-L250Size: 250 µgDry Ice: NoHazardous: No
CAT#:0209-S01-038-L250Size:250 µg
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Description
BAFF Receptor (BAFF-R), a member of the TNFR superfamily, is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells and peripheral blood leukocytes. BAFF-R is a type III transmembrane protein that binds with high specificity to BAFF (TNFSF13B) . BAFF-R/BAFF signaling plays a critical role in B cell survival and maturation. Recombinant human BAFF-R is a 76 amino acid polypeptide (7.7 kDa) corresponding to the extracellular portion of the full BAFF-R protein.
Synonyms
TNFRSF13C; BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin
NCBI Gene ID
115650
UniProt
Q96RJ3
Accession Number
NP_443177
Accession Number mRNA
NM_052945
Chromosomal Location
22q13.1-q13.31
Reactivity
Human
Cross Reactivity
Mouse
Sequence
MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ ESVGAGAGEA ALPLPG
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to block BAFF induced mouse splenocyte survival. The expected ED50 for this effect is 2.0-4.0 μg/ml in the presence of 1.0 μg/ml of human soluble BAFF.
Length
76
Form
Lyophilized
Molecular Weight
7.7 kDa
Host or Source
E. coli

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