TWEAK receptor, soluble

• Description :

  TWEAK-R belongs to the TNF family of transmembrane proteins and contains a cytoplasmic „death domain“, which can activated the cell's apoptotic machinery. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Signal transduction by TWEAK-R can be activated by either the membrane anchored or the soluble TWEAK. Recombinant soluble TWEAK-R is a 53 amino acid polypeptide (5.6 kDa) comprising the entire extracellular domain of the full length TWEAK-R protein.

• Synonyms :

  TNFRSF12A; FN14; CD266; TWEAKR

• NCBI Gene ID :

  51330

• UniProt :

  Q9NP84

• Accession Number :

  NP_057723.1

• Accession Number mRNA :

  NM_016639.2

• Chromosomal Location :

  16p13.3

• Reactivity :

  Human

• Cross Reactivity :

  Human

• Sequence :

  EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by its ability to inhibit TWEAK-induced weak cell death of HT29 cells. The expected ED50 for this effect is 1.0-3.0 µg/ml.

• Length :

  53

• Form :

  Lyophilized

• Molecular Weight :

  5.6 kDa

• Host or Source :

  E. coli