Recombinant Phospho-FADD (S194) Monoclonal Antibody

• Background:

  The protein is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade.

• Abbreviation:

  Phospho-FADD (S194)

• UniProt:

  Q13158

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant human FADD (phospho S194) fragment

• Target:

  GIG; MORT; FADD; GIG3; MORT1; Fas associated via death domain; FADD protein; Fas (TNFRSF6) associated via death domain; Fas associating death domain containing protein; Fas associating protein; Fas associating protein with death domain; Fas TNFRSF6 associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; GIG 3; Growth inhibiting gene 3 protein; Growth-inhibiting gene 3 protein; H sapiens mRNA for mediator of receptor induced toxicity; Mediator of receptor induced toxicity; MGC8528; MORT 1; Protein FADD

• Clonality:

  Monoclonal, Recombinant

• Clone:

  A808

• Conjugation:

  Unconjugated

• Applications:

  WB

• Field of Research:

  Cell Biology; Cancer

• Purification:

  Protein A purified

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:2000

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  23 kDa

• Observed Molecular Weight:

  23 kDa

• Isotype:

  IgG, κ