Recombinant Phospho-CD31 (Tyr713) Monoclonal Antibody

• Background:

  CD31, also named as Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating platelets, monocytes, neutrophils, some T cells, and endothelial cells and modulates cell adhesion, endothelial cell migration, and angiogenesis. CD31 is phosphorylated on Tyr686 at the cytoplasmic carboxy-terminal tail upon various stimuli (e.g. mechanical or oxidative stress), presumably by Src family members. The tyrosine phosphorylation mediates associations with a number of SH2 domain-containing binding partners such as PI3 kinase, SHIP, PLCγ, and SHP-2. Thus, CD31 serves as a scaffold for various signaling molecules.

• Abbreviation:

  Phospho-CD31 (Tyr713)

• UniProt:

  P16284

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Phosphorylated human CD31 (Tyr713) peptide

• Target:

  PECA; cluster of differentiation; PECAM1; CD31; CD31/EndoCAM; GPIIA; PECA1; PECAM-1; endoCAM; cluster of differentiation 31; Platelet endothelial cell adhesion molecule; endocam; Adhesion molecule; CD31 antigen; CD31 EndoCAM; FLJ34100; FLJ58394; GPIIA'; PECAM; Pecam 1; PECAM 1 CD31 EndoCAM; PECAM1; Platelet and endothelial cell adhesion molecule 1; Platelet/endothelial cell adhesion molecule 1; CD31; EndoCAM; GPIIA; PECA1; PECAM-1; Platelet endothelial cell adhesion molecule

• Clonality:

  Monoclonal, Recombinant

• Clone:

  A817

• Conjugation:

  Unconjugated

• Applications:

  WB

• Field of Research:

  Cardiovascular; Signal Transduction; Stem Cells; Cancer

• Purification:

  Protein A purified

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:1000

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  83 kDa

• Observed Molecular Weight:

  130 kDa

• Isotype:

  IgG, κ