Recombinant RXRA Monoclonal Antibody

• Background:

  Retinoid X receptor α (RXRA) is the founding RXR family member and is predominantly expressed in the liver, kidney, epidermis, intestine, and a variety of tissues. Knockout of the murine rxrα gene results in embryonic lethality tentatively due to myocardial hypoplasia, which demonstrates the importance of RXRA in retinoid signaling in vivo. Biochemical evidence suggests that RXRA transcriptional activity is post-translationally regulated through the Ras-Raf-MAPK signaling cascade. MAPK-dependent phosphorylation of RXRα directly abrogates the ability of RXRA to associate with nuclear receptor coactivators.

• Abbreviation:

  RXRA

• UniProt:

  P19793

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant human RXRA fragment

• Target:

  NR2B; NR2B1; RXRA; Retinoid X receptor alpha

• Clonality:

  Monoclonal, Recombinant

• Clone:

  A659

• Conjugation:

  Unconjugated

• Applications:

  WB; IF

• Field of Research:

  Epigenetics and Nuclear Signaling; Signal Transduction; Cancer; Metabolism

• Purification:

  Protein A purified

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:1000; IF 1:50

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  51 kDa

• Observed Molecular Weight:

  56 kDa

• Isotype:

  IgG, κ