Recombinant Cyclin D2 Monoclonal Antibody

• Background:

  Cyclin D2 (CCND2) belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. CCND2 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND2 has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. High level expression of CCND2 was observed in ovarian and testicular tumors.

• Abbreviation:

  Cyclin D2

• UniProt:

  P30279

• Host:

  Rabbit

• Reactivity:

  Human; Rat

• Immunogen:

  Recombinant human Cyclin D2 fragment

• Target:

  CCND; KIAK; MPPH; G1/S-specific cyclin-D; cyclin D; CCND2; KIAK0002; MPPH3; cyclin D2; G1/S-specific cyclin-D2

• Clonality:

  Monoclonal, Recombinant

• Clone:

  A542

• Conjugation:

  Unconjugated

• Applications:

  WB; IHC

• Field of Research:

  Cell Biology; Epigenetics and Nuclear Signaling; Cancer

• Purification:

  Protein A purified

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:2000-1:10000; IHC 1:100-1:1000

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  33 kDa

• Observed Molecular Weight:

  36 kDa

• Isotype:

  IgG, κ