Recombinant MEK2 Monoclonal Antibody

• Background:

  The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax.

• Abbreviation:

  MEK2

• UniProt:

  P36507

• Host:

  Rabbit

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Recombinant human MEK2 fragment

• Target:

  MEK; MKK; CFC; MAPKK; PRKMK; MAP2K; CFC4; MAPKK2; MEK2; MKK2; PRKMK2; MAP2K2; Cardiofaciocutaneous syndrome; CFC syndrome; Dual specificity mitogen activated protein kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; FLJ26075; MAP kinase kinase 2; MAPK / ERK kinase 2; MAPK/ERK kinase 2; MAPKK 2; MEK 2; Microtubule associated protein kinase kinase 2; Mitogen activated protein kinase kinase 2; Mitogen activated protein kinase kinase 2 p45; MKK 2; MP2K2; OTTHUMP00000165826; OTTHUMP00000165827; PRKMK 2

• Clonality:

  Monoclonal, Recombinant

• Clone:

  A302

• Conjugation:

  Unconjugated

• Applications:

  WB; IHC

• Field of Research:

  Signal Transduction; Cancer

• Purification:

  Protein A purified

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:1000; IHC 1:100-1:1000

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  44 kDa

• Observed Molecular Weight:

  44 kDa

• Isotype:

  IgG, κ