Recombinant Optineurin Monoclonal Antibody

• Background:

  This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

• Abbreviation:

  Optineurin

• UniProt:

  Q96CV9

• Host:

  Rabbit

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Recombinant Human Optineurin protein

• Target:

  FIP; HIP; ALS; OPTN; ALS12; FIP2; GLC1E; HIP7; HYPL; NRP; TFIIIA-INTP; Optineurin; OPTN

• Clonality:

  Monoclonal, Recombinant

• Clone:

  1F13

• Conjugation:

  Unconjugated

• Applications:

  WB; IHC

• Field of Research:

  Immunology; Signal Transduction; Neuroscience

• Purification:

  Protein A

• Concentration:

  0.2 mg/mL

• Dilution:

  IHC 1:200-500; WB 1:1000-5000

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  63 kDa

• Observed Molecular Weight:

  74 kDa

• Isotype:

  IgG, κ