Recombinant Notch1 Monoclonal Antibody

• Background:

  Notch 1 (NOTCH1) Homo sapiens This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymph.

• Abbreviation:

  Notch1

• UniProt:

  P46531

• Host:

  Rabbit

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Recombinant Human Notch1 protein

• Target:

  TAN; AOS; AOVD; Activated NOTCH; Neurogenic locus Notch homolog protein; Translocation-associated notch protein TAN; NOTC; AOS5; AOVD1; TAN1; hN1; NOTCH1; Activated NOTCH1; notch 1; Neurogenic locus Notch homolog protein 1; NICD; NOTC1; Notch 1 intracellular domain; Notch homolog 1 translocation associated (Drosophila) ; Translocation-associated notch protein TAN-1; AOS5; AOVD1; hN1; notch 1; TAN1; Notch-1

• Clonality:

  Monoclonal, Recombinant

• Clone:

  8D5

• Conjugation:

  Unconjugated

• Applications:

  WB

• Field of Research:

  Neuroscience; Epigenetics and Nuclear Signaling; Stem Cells; Cardiovascular; Developmental Biology

• Purification:

  Protein A

• Concentration:

  0.2 mg/mL

• Dilution:

  WB 1:1000-5000

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  273 kDa

• Observed Molecular Weight:

  120 kDa

• Isotype:

  IgG, κ