Recombinant Complement C4-B Monoclonal Antibody

• Background:

  Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.

• Abbreviation:

  Complement C4-B

• UniProt:

  P0C0L5

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant human Complement C4-B fragment

• Target:

  CPAMD; Basic C; Basic C4; C4 (Chido Blood Group) ; C4-B; C4B; C4B_2; CO4; CPAMD3

• Clonality:

  Monoclonal, Recombinant

• Clone:

  A146

• Conjugation:

  Unconjugated

• Applications:

  WB; IHC

• Field of Research:

  Immunology

• Purification:

  Protein A purified

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:2000; IHC 1:200-1:1000

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  193 kDa

• Observed Molecular Weight:

  193, 85 kDa

• Isotype:

  IgG, κ