Recombinant PD1 Monoclonal Antibody

• Background:

  The programmed cell death 1 protein (PD1) is an inhibitory receptor expressed on antigen activated T-cells that plays a critical role in the induction and maintenance of immune tolerance to self-antigens. Upon binding to its ligands CD274/PDCD1L1 (PD-L1) and CD273/PDCD1LG2 (PD-L2), PD1 is phosphorylated within its immunoreceptor tyrosine-based switch motif (ITSM), which facilitates the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2. PTPN11/SHP-2 then dephosphorylates key T-cell receptor (TCR) proximal signaling molecules, including ZAP70, PRKCQ/PKC theta and CD247/CD3 zeta, leading to the direct inhibition of T-cell activation. The PD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and evade destruction by the immune system, thereby facilitating tumor survival.

• Abbreviation:

  PD1

• UniProt:

  Q15116

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Synthetic peptide derived from the human PD1 protein

• Target:

  SLEB; hSLE; Programmed Death; programmed cell death; Programmed cell death protein; Systemic lupus erythematosus susceptibility; hPD; PDCD1; CD279; PD-1; PD1; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death 1; PD 1; CD279 antigen; hPD 1; hPD l; PDCD 1; Programmed cell death 1 protein; Programmed Death-1; Protein PD 1; Protein PD-1; Systemic lupus erythematosus susceptibility 2; Programmed cell death protein 1; CD279; CD279 antigen; hPD 1; hPD l; hPD-1; hSLE1; PD 1; PD-1; PD1; PDCD 1; PDCD1; PDCD1; Programmed cell death 1; Programmed cell death 1 protein; Programmed cell death protein 1; Protein PD 1; Protein PD-1; SLEB2; Systemic lupus erythematosus susceptibility 2

• Clonality:

  Monoclonal, Recombinant

• Clone:

  A115

• Conjugation:

  Unconjugated

• Applications:

  IHC; IF

• Field of Research:

  Cell Biology; Immunology; Cancer

• Purification:

  Protein A purified

• Concentration:

  1 mg/mL

• Dilution:

  IHC 1:200-1:1000; IF 1:50

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Isotype:

  IgG, κ