Recombinant PDGFR-β Monoclonal Antibody

• Background:

  This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

• Abbreviation:

  PDGFR-β

• UniProt:

  P09619

• Host:

  Rabbit

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Recombinant Human PDGFR-β protein

• Target:

  IMF; JTK; IBGC; CD140B; IBGC4; IMF1; JTK12; KOGS; PDGFR; PDGFR-1; PDGFR1; PENTT; PDGF Receptor beta; PDGFRB; PDGFR beta; PDGF-Rβ Beta platelet derived growth factor receptor; Beta Platelet-Derived Growth Factor Receptor; Beta-type platelet-derived growth factor receptor; CD 140B; CD140 antigen-like family member B; CD140b antigen; OTTHUMP00000160528; PDGF R beta; PDGFR 1; PDGFR-Beta; PDGF-R-beta; PGFRB; Platelet derived growth factor receptor 1; platelet derived growth factor receptor beta; Platelet derived growth factor receptor beta polypeptide; Platelet-Derived Growth Factor Receptor 1; Platelet-Derived Growth Factor Receptor Beta

• Clonality:

  Monoclonal, Recombinant

• Clone:

  4B12

• Conjugation:

  Unconjugated

• Applications:

  WB

• Field of Research:

  Cardiovascular; Signal Transduction; Cancer

• Purification:

  Protein A

• Concentration:

  0.2 mg/mL

• Dilution:

  WB 1:2000-1:10000

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  124 kDa

• Observed Molecular Weight:

  190 kDa

• Isotype:

  IgG, κ