Recombinant CENP-A Monoclonal Antibody

• Background:

  Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4) 2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

• Abbreviation:

  CENP-A

• UniProt:

  P49450

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant Human CENP-A protein

• Target:

  CenH; CENPA; CENP-A; CenH3

• Clonality:

  Monoclonal, Recombinant

• Clone:

  9F4

• Conjugation:

  Unconjugated

• Applications:

  WB

• Field of Research:

  Epigenetics and Nuclear Signaling

• Purification:

  Protein A

• Concentration:

  0.2 mg/mL

• Dilution:

  WB 1:2000-1:10000

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  16 kDa

• Observed Molecular Weight:

  16 kDa

• Isotype:

  IgG, κ