AIFM2 (CT) Peptide

• Background:

  AIFM2 Antibody: AIFM2 blocks ferroptosis independent of ubiquinol metabolism. AIFM2 is a key component of a non-mitochondrial CoQ antioxidant system that acts in parallel to the canonical glutathione-based GPX4 pathway. AIFM2 confers protection against ferroptosis elicited by GPX4 deletion. AIF-2 was found to be upregulated in human glioma tissues and cell lines. Downregulation of AIF-2 reduced cell proliferation and induced G1 cell cycle arrest. AIF and its family member protein, AMID, are rotenone-sensitive NADH:ubiquinone oxidoreductases (of the NDH-2 type) . AIF-M2 lessens survival cell signaling in the presence of foreign (e.g. bacterial and (retro) viral) cytosolic DNA, thus contributing to the onset of apoptosis

• NCBI Gene ID:

  84883

• Swiss Prot:

  Q9BRQ8

• Accession Number:

  Q9BRQ8

• Type:

  Peptides

• Concentration:

  200 ug/mL

• Buffer:

  PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store AIFM2 (CT) Peptide at -20˚ C, stable for one year.

• Applications Notes:

  AIFM2 (CT) Peptideis used for blocking the activity of theAIFM2 (CT) Antibody

• NCBI Official Name:

  Apoptosis inducing factor mitochondria associated

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Dai et al. Biochem Biophys Res Commun. 2020; 523 (4) :966-971

• Background Reference 02:

  Bersuker et al. Nature 2019; 575 (7784) :688-692

• Background Reference 03:

  Doll et al. Nature 2019; 575 (7784) :693-698

• Background Reference 04:

  Chen et al. J Mol Neurosci 2019; 68 (2) : 304-310

• Background Reference 05:

  Gong et al. J Biol Chem 2007; 282 (41) :30331-30340

• Other Product Names:

  AIMF2

• Tested Applications:

  Blocking

• Species:

  Human

• Protein ID:

  74752283

• Physical Properties:

  Liquid