POLRMT (CT) Peptide

• Background:

  POLRMT Antibody: This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication. POLRMT mutations impair mitochondrial transcription causing neurological disease. Knock-down of MRPL12 by RNA interference results in instability of POLRMT.

• NCBI Gene ID:

  5442

• Swiss Prot:

  O0411

• Accession Number:

  O0411.2

• Type:

  Peptides

• Concentration:

  200 ug/mL

• Buffer:

  PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store ULBP1 peptide at -20˚ C, stable for one year.

• Applications Notes:

  POLRMT (CT) Peptide is used for blocking the activity of POLRMT (CT) Antibody.

• NCBI Official Name:

  RNA polymerase mitochondrial

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Inatomi et al. Biochim Biophys Acta Mol Cell Res. 2022; 1869 (1) ; 119167

• Background Reference 02:

  Olahova et al. Nat Commun. 2021; 12 (1) :1135

• Background Reference 03:

  Nouws et al. J Biol Chem 2016; 291 (2) :989-997

• Other Product Names:

  DNA-directed RNA polymerase, mitochondrial, MtRPOL, POLRMT Isoforms

• Tested Applications:

  Blocking

• Species:

  Human

• Protein ID:

  50403691

• Physical Properties:

  Liquid