Products for Research Use Only

Osteonectin Recombinant Protein

CAT: 0223-40-571-01Size: 0.01 mgDry Ice: NoHazardous: No
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CAT#:0223-40-571-01Size:0.01 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SPARC/Osteonectin is a secreted, evolutionarily conserved collagen-binding glycoprotein that is involved in a variety of cellular activities. It is highly expressed in tissues undergoing morphogenesis, remodeling and wound repair. SPARC/Osteonectin and its related peptides bind to numerous proteins of the extracellular matrix (ECM), affect ECM protein expression, influence cellular adhesion and migration, and modulate growth factor-induced cell proliferation and angiogenesis. SPARC/Osteonectin consists of three domains; an N-terminal acidic region that binds calcium ions with low affinity, a module containing two EF-hand motifs that bind calcium with high affinity, and a cysteine-rich follistatin-like domain. Recombinant human SPARC/Osteonectin is a glycoprotein containing 286 amino acids that migrates at an apparent MW of 43.7 kDa by SDS-PAGE analysis due to the effect of glycosylation.
NCBI Gene ID
6678
Swiss Prot
P09486
Accession Number
NP_003109.1
Type
Recombinant Proteins
Source
CHO cells
Field of Research
Cancer, Cell Cycle, Signal Transduction, Stem Cell
Purity
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Shipping Conditions
Room Temp
Storage Conditions
The lyophilized Osteonectin recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted Osteonectin stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing Osteonectin recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
NCBI Official Name
Secreted protein, acidic, cysteine-rich (osteonectin)
NCBI Organism
Homo sapiens
Other Product Names
ON, ON, SPARC, Basement-membrane protein 40, BM-40
Species
Human
Protein ID
4507171
Physical Properties
Lyophilized