Osteonectin Recombinant Protein

• Background:

  SPARC/Osteonectin is a secreted, evolutionarily conserved collagen-binding glycoprotein that is involved in a variety of cellular activities. It is highly expressed in tissues undergoing morphogenesis, remodeling and wound repair. SPARC/Osteonectin and its related peptides bind to numerous proteins of the extracellular matrix (ECM), affect ECM protein expression, influence cellular adhesion and migration, and modulate growth factor-induced cell proliferation and angiogenesis. SPARC/Osteonectin consists of three domains; an N-terminal acidic region that binds calcium ions with low affinity, a module containing two EF-hand motifs that bind calcium with high affinity, and a cysteine-rich follistatin-like domain. Recombinant human SPARC/Osteonectin is a glycoprotein containing 286 amino acids that migrates at an apparent MW of 43.7 kDa by SDS-PAGE analysis due to the effect of glycosylation.

• NCBI Gene ID:

  6678

• Swiss Prot:

  P09486

• Accession Number:

  NP_003109.1

• Type:

  Recombinant Proteins

• Source:

  CHO cells

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction, Stem Cell

• Purity:

  Greater than 98% by SDS-PAGE gel and HPLC analyses.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized Osteonectin recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted Osteonectin stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing Osteonectin recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Secreted protein, acidic, cysteine-rich (osteonectin)

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  ON, ON, SPARC, Basement-membrane protein 40, BM-40

• Species:

  Human

• Protein ID:

  4507171

• Physical Properties:

  Lyophilized