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GDNF Recombinant Protein

CAT: 0223-40-499-01Size: 0.002 mgDry Ice: NoHazardous: No
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CAT#:0223-40-499-01Size:0.002 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
GDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRalpha (alpha1-alpha4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using Parkinson's disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional human GDNF ligand is a disulfide-linked homodimer, of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, one of which (Cys 101) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.
NCBI Gene ID
2668
Swiss Prot
P39905
Accession Number
NP_000505.1
Type
Recombinant Proteins
Source
E. coli
Field of Research
Growth Factors
Shipping Conditions
Room Temp
Storage Conditions
The lyophilized GDNF recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted GDNF is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing GDNF recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
NCBI Official Name
Glial cell derived neurotrophic factor
NCBI Organism
Homo sapiens
Other Product Names
ATF1, ATF2, HSCR3, HFB1-GDNF, Glial cell line-derived neurotrophic factor, Astrocyte-derived trophic factor, hGDNF
Species
Human
Protein ID
4503975
Physical Properties
Lyophilized

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