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Noggin Recombinant Protein

CAT: 0223-40-445-01Size: 0.005 mgDry Ice: NoHazardous: No
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CAT#:0223-40-445-01Size:0.005 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2, -7, -13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant murine Noggin is a 46.4 kDa disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains.
NCBI Gene ID
18121
Swiss Prot
P97466
Accession Number
NP_032737.1
Type
Recombinant Proteins
Source
E. coli
Shipping Conditions
Room Temp
Storage Conditions
The lyophilized Noggin recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted Noggin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing Noggin recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
NCBI Official Name
Noggin
NCBI Organism
Mus musculus
Other Product Names
Noggin
Species
Murine
Protein ID
7110675
Physical Properties
Lyophilized

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