Galectin-3 Recombinant Protein

• Background:

  Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with beta-galactoside moieties. Galectin-3 regulates a number of biological processes, including embryogenesis, inflammatory responses, cell progression and metastasis. Galectin-3 is normally expressed in epithelia of a variety of tissues, including colon and endometrium, and in various inflammatory cells, including macrophages. Galectin-3 can function intracellularly, in controlling cell cycle and preventing T-cell apoptosis, and also extracellularly, in activating various cells, including monocytes/macrophages, mast cells, neutrophils, and lymphocytes. Expression of Galectin-3 is affected by neoplastic transformation, being up-regulated in certain types of lymphomas, and in thyroid and hepatic carcinomas. Conversely, it is down-regulated in other cancers, such as colon, breast, ovarian, and uterine. Recombinant human Galectin-3 is a globular 26.0kDa protein containing 250 amino acid residues, but no disulfide bonds.

• NCBI Gene ID:

  3958

• Swiss Prot:

  P17931

• Accession Number:

  NP_002297.2

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Cell Cycle, Neuroscience, Other

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized Galectin-3 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted Galectin-3 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing Galectin-3 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Lectin, galactoside-binding, soluble, 3

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  L31, GAL3, MAC2, CBP35, GALBP, GALIG, LGALS2, Galectin-3, 35 kDa lectin, Gal-3

• Species:

  Human

• Protein ID:

  115430223

• Physical Properties:

  Lyophilized