LIGHT Recombinant Protein

CAT: 0223-40-301-01Size: 0.003 mgDry Ice: NoHazardous: No
CAT#:0223-40-301-01Size:0.003 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
LIGHT belongs to the TNF family of ligands, and can signal through the herpes virus entry mediator type A receptor (HVEM, TNFRSF14), LTβ R, or bind to a decoy receptor, DcR3. It is expressed in splenocytes, activated PBL, CD+8 tumor infiltrating lymphocytes, granulocytes, and monocytes. LIGHT has the ability to active NFκ B, to co-stimulate the activation of lymphocytes and to induce apoptosis in certain human tumor cells. Recombinant human LIGHT has a calculated mass of 19.3 kDa containing 177 amino acid residues. Due to glycosylation LIGHT migrates between 20.0-22.5 kDa by SDS-PAGE under non-reducing conditions.
NCBI Gene ID
8740
Swiss Prot
O43557
Accession Number
NP_003798.2
Type
Recombinant Proteins
Source
High-5 Insect cells
Field of Research
Apoptosis, Chemokines & Cytokines, Immunology, Infectious Disease, Innate Immunity, Signal Transduction
Shipping Conditions
Room Temp
Storage Conditions
The lyophilized LIGHT recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted LIGHT is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing LIGHT recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
NCBI Official Name
Tumor necrosis factor (ligand) superfamily, member 14
NCBI Organism
Homo sapiens
Other Product Names
LTg, TR2, CD258, HVEML, LIGHT, UNQ391/PRO726, Tumor necrosis factor ligand superfamily member 14, Herpes virus entry mediator ligand, HVEM-L
Species
Human
Protein ID
25952144
Physical Properties
Lyophilized

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