LIGHT Recombinant Protein

• Background:

  LIGHT belongs to the TNF family of ligands, and can signal through the herpes virus entry mediator type A receptor (HVEM, TNFRSF14), LTβ R, or bind to a decoy receptor, DcR3. It is expressed in splenocytes, activated PBL, CD+8 tumor infiltrating lymphocytes, granulocytes, and monocytes. LIGHT has the ability to active NFκ B, to co-stimulate the activation of lymphocytes and to induce apoptosis in certain human tumor cells. Recombinant human LIGHT has a calculated mass of 19.3 kDa containing 177 amino acid residues. Due to glycosylation LIGHT migrates between 20.0-22.5 kDa by SDS-PAGE under non-reducing conditions.

• NCBI Gene ID:

  8740

• Swiss Prot:

  O43557

• Accession Number:

  NP_003798.2

• Type:

  Recombinant Proteins

• Source:

  High-5 Insect cells

• Field of Research:

  Apoptosis, Chemokines & Cytokines, Immunology, Infectious Disease, Innate Immunity, Signal Transduction

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized LIGHT recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted LIGHT is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing LIGHT recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Tumor necrosis factor (ligand) superfamily, member 14

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  LTg, TR2, CD258, HVEML, LIGHT, UNQ391/PRO726, Tumor necrosis factor ligand superfamily member 14, Herpes virus entry mediator ligand, HVEM-L

• Species:

  Human

• Protein ID:

  25952144

• Physical Properties:

  Lyophilized