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TNF beta Recombinant Protein

CAT: 0223-40-275-01Size: 0.005 mgDry Ice: NoHazardous: No
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CAT#:0223-40-275-01Size:0.005 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TNF-β is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands and signals through TNFR1 and TNFR2. TNF-β is produced by activated T and B lymphocytes, and has similar activities to TNF-alpha. Like TNF-α , TNF-β is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-β is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-β , which effectively anchors the TNF-β to the cell surface. TNF-β is cytotoxic to a wide range of tumor cells. Recombinant human TNF-β is a secreted 171 amino acid protein (18.6 kDa) which forms an active non-disulfide linked homotrimer structure in solution.
NCBI Gene ID
4049
Swiss Prot
P01374
Accession Number
NP_000586.2
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cancer, Immunology, Signal Transduction
Shipping Conditions
Room Temp
Storage Conditions
The lyophilized TNF beta recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted TNF beta is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing TNF beta recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
NCBI Official Name
Lymphotoxin alpha
NCBI Organism
Homo sapiens
Other Product Names
LT, TNFB, TNFSF1, Lymphotoxin-alpha, TNF-beta, LT-alpha
Species
Human
Protein ID
6806893
Physical Properties
Lyophilized

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