IL-17A Recombinant Protein

• Background:

  The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant human IL-17A is a 31.0 kDa disulfide-linked homodimer of two 136 amino acid polypeptide chains.

• NCBI Gene ID:

  3605

• Swiss Prot:

  Q16552

• Accession Number:

  NP_002181.1

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Chemokines & Cytokines, Immunology, Innate Immunity, Signal Transduction

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized IL-17A recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted IL-17A is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing IL-17A recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Interleukin 17A

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  IL17, CTLA8, IL-17, IL-17A, IL17, Interleukin-17A, Cytotoxic T-lymphocyte-associated antigen 8

• Species:

  Human

• Protein ID:

  4504651

• Physical Properties:

  Lyophilized