IL-17A Antibody [17B7] (FITC)

• Background:

  The 17B7 monoclonal antibody specifically binds to mouse and rat IL-17A, a pro-inflammatory cytokine. It is produced by T helper 17 (Th17) cells, a unique subset of IL-23 dependent CD4+ T cells. Interleukin-17A is highly expressed in transplant rejection, asthma, psoriasis, and multiple sclerosis, and enhances the expression of ICAM-1 in human fibroblasts. The homodimer is expressed by activated peripheral CD4+ T lymphocytes. The Interleukin-17A binds to the IL-17 receptors (IL-17R) expressed by mast cells, monocytes and macrophages, fibroblasts, and endothelial and epithelial cells.

• NCBI Gene ID:

  16171;301289

• Swiss Prot:

  Q62386; Q61453

• Host:

  Rat

• Reactivity:

  Mouse, Rat

• Clonality:

  Monoclonal

• Clone:

  17B7

• Conjugation:

  FITC

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Chemokines & Cytokines, Growth Factors

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

• Fragment:

  Rat IgG2a, kappa

• Specificity:

  The 17B7 monoclonal antibody specifically binds to mouse and rat IL-17A, a pro-inflammatory cytokine.

• Symbol:

  Il17a

• NCBI Official Name:

  Interleukin 17A

• NCBI Organism:

  Mus musculus; Rattus norvegicus

• Other Product Names:

  Il17, Ctla8, IL-17, Ctla-8, IL-17A, Il17a

• Tested Applications:

  Flow

• Physical Properties:

  Liquid