DKK-1 Recombinant Protein

• Background:

  DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β -catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β catenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β catenin signaling cascade. It has been suggested that by inhibiting Wnt/β -catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

• NCBI Gene ID:

  22943

• Swiss Prot:

  O94907

• Accession Number:

  NP_036374.1

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Cell Cycle, Immunology, Signal Transduction

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized DKK-1 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted DKK-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing DKK-1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Dickkopf WNT signaling pathway inhibitor 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  SK, DKK-1, Dickkopf-related protein 1, SK, Dickkopf-1

• Species:

  Human

• Protein ID:

  7110719

• Physical Properties:

  Lyophilized