PDGF-BB Recombinant Protein

• Background:

  PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α -granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β . PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids) .

• NCBI Gene ID:

  5155

• Swiss Prot:

  P01127

• Accession Number:

  NP_002599.1

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Growth Factors, Signal Transduction

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized PDGF-BB recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted PDGF-BB is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing PDGF-BB recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Platelet-derived growth factor beta polypeptide

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  SIS, SSV, IBGC5, PDGF2, c-sis, PDGF-2, SIS, Platelet-derived growth factor subunit B, PDGF subunit B

• Species:

  Human

• Protein ID:

  4505681

• Physical Properties:

  Lyophilized