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BMP-2 Recombinant Protein

CAT: 0223-40-106-01Size: 0.002 mgDry Ice: NoHazardous: No
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CAT#:0223-40-106-01Size:0.002 mg
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Background
BMPs (Bone Morphogenetic Proteins) belong to the TGF-beta superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease. Recombinant human BMP-2 is a 26.0 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains.
NCBI Gene ID
650
Swiss Prot
P12643
Accession Number
NP_001191.1
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cancer, Cell Cycle, Growth Factors, Signal Transduction, Stem Cell
Shipping Conditions
Room Temp
Storage Conditions
The lyophilized BMP-2 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted BMP-2 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing BMP-2 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
NCBI Official Name
Bone morphogenetic protein 2
NCBI Organism
Homo sapiens
Other Product Names
BDA2, BMP2A, Bone morphogenetic protein 2, Bone morphogenetic protein 2A, BMP-2
Species
Human, Mouse, Rat
Protein ID
4557369
Physical Properties
Lyophilized

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