BMP-2 Recombinant Protein

• Background:

  BMPs (Bone Morphogenetic Proteins) belong to the TGF-beta superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease. Recombinant human BMP-2 is a 26.0 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains.

• NCBI Gene ID:

  650

• Swiss Prot:

  P12643

• Accession Number:

  NP_001191.1

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Cancer, Cell Cycle, Growth Factors, Signal Transduction, Stem Cell

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized BMP-2 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted BMP-2 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing BMP-2 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Bone morphogenetic protein 2

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  BDA2, BMP2A, Bone morphogenetic protein 2, Bone morphogenetic protein 2A, BMP-2

• Species:

  Human, Mouse, Rat

• Protein ID:

  4557369

• Physical Properties:

  Lyophilized