IL-31 Antibody [SB118b]

• Background:

  Interleukin-31 (IL-31) is a 24 kDa alpha-helical protein and a member of the IL-6 family of cytokines that is preferentially expressed by CD4+ T cells. This cytokine elicits its response by binding to a heterodimeric complex consisting of a gp130-like receptor chain and the oncostatin M receptor subunit. On target cells which include a broad range of immune and non-immune cells, IL-31 binding can induce activation of the Jak/STAT, AKT, and MAPK signaling pathways. Due to the ubiquitous expression of its receptor complex, IL-31 has numerous physiological roles that include regulating hematopoiesis and immune response. Over-expression has been linked to chronic inflammatory states such as dermatitis, pruritus, airway hypersensitivity, and inflammatory bowel disease.

• NCBI Gene ID:

  386653

• Swiss Prot:

  Q6EBC2

• Accession Number:

  Q6EBC2

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  E. coli-expressed human IL-31

• Clonality:

  Monoclonal

• Clone:

  [SB118b]

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Chemokines & Cytokines

• Concentration:

  1.0 mg/mL

• Buffer:

  Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store vial at 2-8˚ C

• Fragment:

  IgG2b

• Specificity:

  IL-31

• Applications Notes:

  IL-31 Antibody [SB118b] for use in ELISA assays.

• Symbol:

  IL31

• NCBI Official Name:

  Interleukin 31

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Interleukin-31

• Tested Applications:

  Flow, FLISA

• Physical Properties:

  Liquid