IL-31 Antibody (biotin)

• Background:

  Interleukin 31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia and skin lesions, and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.

• NCBI Gene ID:

  386653

• Swiss Prot:

  Q6EBC2

• Accession Number:

  Q6EBC2

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hIL-31. Human IL-31 specific antibody was purified by affinity chromatography and then biotinylated.

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Primary Antibodies, Antibody Pairs

• Field of Research:

  Immunology, Chemokines & Cytokines

• Concentration:

  Batch dependent

• Modification:

  None

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  IL-31 antibody is stable for at least 2 years from date of receipt at -20˚ C. The reconstituted antibody is stable for at least two weeks at 2-8˚ C. Frozen aliquots are stable for at least 6 months when stored at -20˚ C. Avoid repeated freeze-thaw cycles.

• Symbol:

  IL31

• NCBI Official Name:

  Interleukin 31

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  IL-31Interleukin-31IL-31

• Tested Applications:

  ELISA, WB

• Protein ID:

  74709232

• Physical Properties:

  Lyophilized