IL-31

• Description:

  Human IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor) . GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Recombinant IL-31 is a 15.8 kDa protein containing 141 amino acid residues.

• Synonyms:

  IL31; IL-31

• NCBI Gene ID:

  386653

• UniProt:

  Q6EBC2

• Accession Number:

  NP_001014358.1

• Accession Number mRNA:

  NM_001014336.1

• Chromosomal Location:

  12q24.31

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Measured by its ability to induce STAT3 activation in human U87 cells.

• Length:

  141

• Form:

  Lyophilized

• Molecular Weight:

  15.8 kDa

• Host or Source:

  E. coli