CD11b Antibody [M1/70] (Cy5)

• Background:

  CD11b, the integrin alphaM subunit, combines with CD18, the integrin beta2 subunit, to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1/CD54. Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. Mac-1 expression is rapidly up-regulated on neutrophils after activation and in the same time period that CD62L is shed from the cell surface. In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process, Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils. Cross-reaction of M1/70 to human CD11b has been observed on monocytes, polymorphonuclear leukocytes, and NK cells.

• NCBI Gene ID:

  16409

• Swiss Prot:

  P05555

• Accession Number:

  P05555

• Host:

  Rat

• Reactivity:

  Mouse, Human, Rhesus Monkey, Baboon, Rabbit

• Immunogen:

  C57BL/10 mouse splenic T cells and concanavalin A-activated C57BL/10 splenocytes

• Clonality:

  Monoclonal

• Clone:

  [M1/70]

• Conjugation:

  Cy5

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Neuroscience, Signal Transduction

• Concentration:

  0.1 mg/mL

• Buffer:

  Supplied in PBS/NaN3

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store vial at 2-8˚ C

• Fragment:

  IgG2b

• Specificity:

  CD11b

• Applications Notes:

  CD11b Antibody [M1/70] for use in flow cytometry and immunohistochemistry / immunocytochemistry assays.

• Symbol:

  Itgam

• NCBI Official Name:

  Integrin alpha M

• NCBI Organism:

  Mus musculus

• Other Product Names:

  Integrin alphaM, Mac-1alpha, Mac-1, Mo1, CR3, C3biR

• Tested Applications:

  ELISA, WB, IP

• Physical Properties:

  Liquid