C Fos Antibody

• Background:

  Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.

• NCBI Gene ID:

  2353

• Swiss Prot:

  P01100

• Accession Number:

  NP_005243.1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  C-Fos antibody was raised against a peptide sequence around aa.28~32 (S-Y-Y-H-S) derived from Human C-Fos.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  62 kDa

• Specificity:

  This antibody detects endogenous level of total C-Fos protein.

• Applications Notes:

  Western Blot: 1:500~1:1000

• Symbol:

  FOS

• NCBI Official Name:

  FBJ murine osteosarcoma viral oncogene homolog

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Okazaki K., Sagata N. EMBO J. 14:5048-5059 (1995) Zhang Y., Feng X. H., Derynck R. Nature 394:909-913 (1998) Bossis G., Malnou C. E., Farras R., Andermarcher E., Hipskind R., Rodriguez M., Schmidt D., Muller S., Jariel-Encontre I., Piechaczyk M. Mol. Cell. Biol. 25:6964-6979 (2005)

• Other Product Names:

  P55, AP-1, C-FOS, p55

• Tested Applications:

  WB

• Protein ID:

  4885241

• Physical Properties:

  Liquid