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Ring1A Antibody

CAT: 0223-79-730Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-730Size:0.1 mg
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Background
Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.
NCBI Gene ID
6015
Swiss Prot
Q06587
Accession Number
NP_002922.2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Ring1A antibody was raised against a peptide sequence around aa.35~39 (I-A-V-S-P) derived from Human Ring1A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
58 kDa
Specificity
This antibody detects endogenous level of total Ring1A protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
RING1
NCBI Official Name
Ring finger protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Cao R., Tsukada Y., Zhang Y. Mol. Cell 20:845-854 (2005) Satijn D. P. E., Gunster M. J., van der Vlag J., Hamer K. M., Schul W., Alkema M. J., Saurin A. J., Freemont P. S., van Driel R., Otte A. P. Mol. Cell. Biol. 17:4105-4113 (1997)
Other Product Names
RNF1, RING1A, RNF1, RING1
Tested Applications
WB
Protein ID
51479192
Physical Properties
Liquid

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