ERAB Antibody

• Background:

  Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) .

• NCBI Gene ID:

  3028

• Swiss Prot:

  Q99714

• Accession Number:

  NP_004484.1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  ERAB antibody was raised against a peptide sequence around aa.253~257 (L-D-G-A-I) derived from Human ERAB.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  27 kDa

• Specificity:

  This antibody detects endogenous level of total ERAB protein.

• Applications Notes:

  Western Blot: 1:500~1:1000

• Symbol:

  HSD17B10

• NCBI Official Name:

  Hydroxysteroid (17-beta) dehydrogenase 10

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Holzmann J., Frank P., Loeffler E., Bennett K. L., Gerner C., Rossmanith W. Cell 135:462-474 (2008)

• Other Product Names:

  ABAD, CAMR, ERAB, HCD2, MHBD, HADH2, MRPP2, MRX17, MRX31, SCHAD, MRXS10, SDR5C1, 17b-HSD10, DUPXp11.22, ABAD

• Tested Applications:

  WB

• Protein ID:

  4758504

• Physical Properties:

  Liquid