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PKM2 Antibody

CAT: 0223-79-702Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0223-79-702Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
NCBI Gene ID
5315
Swiss Prot
P14618-1
Accession Number
NP_872270.1
Host
Rabbit
Reactivity
Human
Immunogen
PKM2 antibody was raised against a peptide sequence around aa.405~409 (T-S-D-P-T) derived from Human PKM2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
60 kDa
Specificity
This antibody detects endogenous levels of total PKM2 protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
PKM
NCBI Official Name
Pyruvate kinase, muscle
NCBI Organism
Homo sapiens
Background Reference 01
Christofk, H. R. et al. (2008) Nature 452, 230-3. Mazurek, S. et al. (2005) Semin Cancer Biol 15, 300-8. Dombrauckas, J. D. et al. (2005) Biochemistry 44, 9417-29. Hitosugi, T. et al. (2009) Sci Signal 2, ra73.
Other Product Names
PK3, TCB, OIP3, PKM2, CTHBP, THBP1, HEL-S-30, CAGH44, TNRC10, PKM, PK3, PK2
Tested Applications
WB
Protein ID
33286420
Physical Properties
Liquid

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