ASH2L Antibody

• Background:

  Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.

• NCBI Gene ID:

  9070

• Swiss Prot:

  Q9UBL3

• Accession Number:

  NP_004665.2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  ASH2L antibody was raised against a peptide sequence around aa.620~624 (G-R-R-S-P) derived from Human ASH2L.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  65, 80 kDa

• Specificity:

  This antibody detects endogenous level of total ASH2L protein.

• Applications Notes:

  Western Blot: 1:500~1:1000

• Symbol:

  ASH2L

• NCBI Official Name:

  Ash2 (absent, small, or homeotic) -like (Drosophila)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Wysocka J., Myers M. P., Laherty C. D., Eisenman R. N., Herr W. Genes Dev. 17:896-911 (2003) Patel A., Dharmarajan V., Vought V. E., Cosgrove M. S. J. Biol. Chem. 284:24242-24256 (2009)

• Other Product Names:

  ASH2, Bre2, ASH2L1, ASH2L2, ASH2

• Tested Applications:

  WB

• Protein ID:

  157412280

• Physical Properties:

  Liquid