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REST Antibody

CAT: 0223-79-672Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-672Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
NCBI Gene ID
5978
Swiss Prot
Q13127
Accession Number
NP_001180437.1
Host
Rabbit
Reactivity
Human
Immunogen
REST antibody was raised against a peptide sequence around aa.873~877 (R-E-E-A-S) derived from Human REST.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
121 kDa
Specificity
This antibody detects endogenous level of total REST protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
REST
NCBI Official Name
RE1-silencing transcription factor
NCBI Organism
Homo sapiens
Background Reference 01
Chong J. A. et. al. (1995) Cell 80:949-957Schoenherr C. J. et. al. (1995) Science 267:1360-1363Scholl T. et. al. (1996) J. Immunol. 156:1448-1457Lunyak V. V. et. al. (2002) Science 298:1747-1752
Other Product Names
XBR, NRSF, RNF53, XBR, REST
Tested Applications
WB
Protein ID
301897977
Physical Properties
Liquid

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