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GRASP Antibody

CAT: 0223-79-659Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-659Size:0.1 mg
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Background
GRASP (GRP1-associated scaffold protein, tamalin) is a 395 amino acid proteinencoded by the human gene GRASP . GRASP is a scaffold protein that com-prises multiple protein-interacting domains, including a 95 kDa postsynapticdensity protein (PSD-95) /discs-large/ZO-1 (PDZ) domain, a leucine-zipperregion and a carboxyl-terminal PDZ-binding motif. GRASP is involved withintracellular trafficking and contributes to the macromolecular organizationof group 1 metabotropic glutamate receptors (mGluRs) at synapses. GRASPforms a heteromer composed of GRASP , PSCD2 and at least one mGluR-1. Italso interacts with PSCD3, mGluR-2, mGluR-3 and mGluR-5. GRASP is highlyexpressed in brain and has lower levels of expression in lung, heart, embryo, kidney and ovary.
NCBI Gene ID
56850
Swiss Prot
Q9JHZ4
Accession Number
NP_064522.3
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
GRASP antibody was raised against a peptide sequence around aa. 814-818 (Q-E-I-V-R) derived from Rat GRASP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
95 kDa
Specificity
This antibody detects endogenous level of total GRASP protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
GRIPAP1
NCBI Official Name
GRIP1 associated protein 1
NCBI Organism
This antibody was raised against a peptide sequence around aa. 814-818 (Q-E-I-V-R) derived from Rat GRASP
Background Reference 01
Kitano, J., Kimura, K., Yamazaki, Y., Soda, T., Shigemoto, R., Nakajima, Y. and Nakanishi, S. 2002. Tamalin, J. Neurosci. 22:1280-1289. Hall, B. S., Gabernet-Castello, C., Voak, A., Goulding, D., Natesan, S. K. and Field, M. C. 2006. J. Biol. Chem. 281: 27600-27612. Sugi, T., Oyama, T., Muto, T., Nakanishi, S., Morikawa, K. and Jingami, H. 2007. Crystal structures of autoinhibitory PDZ domain of Tamalin EMBO J. 26: 2192-2205.
Other Product Names
GRASP-1, Gripap, Grasp, GRIP1-associated protein
Tested Applications
WB
Protein ID
46592991
Physical Properties
Liquid

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