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EWS Antibody

CAT: 0223-79-651Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-651Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t (11;22) (q24; q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.
NCBI Gene ID
2130
Swiss Prot
Q9BZD1
Accession Number
NP_053733.2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
EWS antibody was raised against a peptide sequence around aa.213~217 (T-Y-G-Q-P) derived from Human EWS.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
85 kDa
Specificity
This antibody detects endogenous levels of total EWS protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
EWSR1
NCBI Official Name
EWS RNA-binding protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Ubhi T. B. S., Rainey D. R., Craig A. R., Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Other Product Names
EWS, bK984G1.4, EWSR1
Tested Applications
WB
Protein ID
253970500
Physical Properties
Liquid

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