ASPSCR1 Antibody

• Background:

  Tug (Tether containing UBX domain for GLUT4), also known as ASPL, ASPSCR1, RCC17, UBXD9, UBXN9, was first identified as a chromosomal translocation partner for TFE3 in patients with Alveolar soft part sarcoma and contains an UBX-like domain in its C-terminal region. Tug is found to tether GLUT4 in intracellular vesicles and to release GLUT4 for cell surface translocation upon insulin stimulation . Stable Tug depletion or expression of a dominant negative form stimulates GLUT4 redistribution.

• NCBI Gene ID:

  79058

• Swiss Prot:

  Q9BZE9

• Accession Number:

  NP_076988.1

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  ASPSCR1 antibody was raised against a peptide sequence around aa.303 ~307 (P-Q-Q-E-Q) derived from Human ASPSCR1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  70 - 75 kDa

• Specificity:

  This antibody detects endogenous levels of total ASPSCR1 protein.

• Applications Notes:

  Western Blot: 1:500~1:1000

• Symbol:

  ASPSCR1

• NCBI Official Name:

  Alveolar soft part sarcoma chromosome region, candidate 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ladanyi, M. et al. (2001) Oncogene 20, 48-57. Bogan, J. S. et al. (2003) Nature 425, 727-33. Yu, C. et al. (2007) J Biol Chem 282, 7710-22.

• Other Product Names:

  TUG, ASPL, ASPS, RCC17, UBXD9, UBXN9, ASPCR1, HSP27, HSP28, TUG

• Tested Applications:

  WB

• Protein ID:

  13129078

• Physical Properties:

  Liquid