CD8a Antibody [Hit8a] (APC)

CAT: 0223-76-645Size: 25 TestsDry Ice: NoHazardous: No
CAT#:0223-76-645Size:25 Tests
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
The Hit8a monoclonal antibody reacts with the human CD8a molecule, a 32 kDa cell surface receptor expressed either as a heterodimer (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha) on the majority of thymocytes, a subpopulation of mature T cells, and natural killer cells. CD8 interacts with the major histocompatibility complex class I (MHC class I) molecules on antigen-presenting cells or epithelial cells. The Hit8a antibody reacts with 13-48% of peripheral lymphocytes, 80% of thymocytes, and a subset of natural killer cells. HIT8a, RPA-T8, and OKT8 antibodies do not compete with each other for binding to peripheral leukocytes, meaning that that they do not recognize the same epitope or block each other by steric hindrance.
NCBI Gene ID
925
Swiss Prot
P01732
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
Hit8a
Conjugation
APC
Type
Primary Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Fragment
Mouse IgG1, kappa
Specificity
The Hit8a monoclonal antibody reacts with the human CD8a molecule, a 32 kDa cell surface receptor expressed either as a heterodimer (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha) on the majority of thymocytes, a subpopulation of mature T cells, and natural killer cells.
Symbol
CD8A
NCBI Official Name
CD8a molecule
NCBI Organism
Homo sapiens
Background Reference 01
Salem, M. L., Hossain, M. S. (2000) . In vivo acute depletion of CD8+ T cells before murine cytomegalovirus infection upregulated innate antiviral activity of natural killer cells. International journal of immunopharmacology,22 (9), 707-718.
Background Reference 02
Kruisbeek, A. M. (1991) . In Vivo Depletion of CD4 and CD8 Specific T Cells.Current protocols in immunology, 4-1.
Background Reference 03
Davies, A., Kalb, S., Liang, B., Aldrich, C. J., Lemonnier, F. A., Jiang, H., ... Soloski, M. J. (2003) . A peptide from heat shock protein 60 is the dominant peptide bound to Qa-1 in the absence of the MHC class Ia leader sequence peptide Qdm.The Journal of Immunology,170 (10), 5027-5033.
Other Product Names
CD8, MAL, p32, Leu2, CD8A
Tested Applications
Flow
Physical Properties
Liquid

Related Products

CatalogName
76-637CD8a Antibody [Hit8a]
76-640CD8a Antibody [Hit8a] (FITC)
76-641CD8a Antibody [Hit8a] (FITC)
76-642CD8a Antibody [Hit8a] (PE)
76-643CD8a Antibody [Hit8a] (PE)
76-638CD8a Antibody [Hit8a] (Violet-450)
76-639CD8a Antibody [Hit8a] (Violet-450)
76-673CD8a Antibody [OKT8] (APC)
76-672CD8a Antibody [OKT8] (APC)
76-674CD8a Antibody [OKT8] (APC)

Alternative Products

CatalogName
MBS4165241-01APC Anti-Human CD8a (Hit8a)
QAB20-APC-25TestsAnti-CD8a Antibody [Hit8a], APC-25Tests
QAB20-APC-100TestsAnti-CD8a Antibody [Hit8a], APC-100Tests
QAB20-V450-100TestsAnti-CD8a Antibody [Hit8a], V450-100Tests
MBS2579636-01Fluor700 Anti-Human CD8a Antibody [HIT8a]
RD30663F-01PE Anti-Human CD8a Antibody[HIT8a]
RD30664F-01AF488 Anti-Human CD8a Antibody[HIT8a]
E-AB-F1271C-01FITC Anti-Human CD8a Antibody[HIT8a]
MBS2572117-01PE Anti-Human CD8a Antibody [HIT8a]
QAB20-V450-25TestsAnti-CD8a Antibody [Hit8a], V450-25Tests

Popular Products