CD66b Antibody [G10F5] (FITC)

• Background:

  The G10F5 monoclonal antibody specifically reacts with human CD66b, a 100kDa glycosylphosphatidylinositol (GPI) linked protein in the granulocyte-specific activation family. CD66b is expressed on granulocytes, neutrophils, and eosinophils. It is reported that this molecule plays a role in regulating neutrophil activation and cellular adhesion. It was previously classified as CD67, but renamed CD66b in the Fifth HLDA Workshop.

• NCBI Gene ID:

  1088

• Swiss Prot:

  P31997

• Host:

  Mouse

• Reactivity:

  Human

• Clonality:

  Monoclonal

• Clone:

  G10F5

• Conjugation:

  FITC

• Type:

  Primary Antibodies

• Field of Research:

  Innate Immunity

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

• Fragment:

  Mouse IgM, kappa

• Specificity:

  The G10F5 monoclonal antibody specifically reacts with human CD66b, a 100kDa glycosylphosphatidylinositol (GPI) linked protein in the granulocyte-specific activation family.

• Symbol:

  CEACAM8

• NCBI Official Name:

  Carcinoembryonic antigen-related cell adhesion molecule 8

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Schlossman, S. F. (1995) .Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.

• Background Reference 02:

  Lund-Johansen, F. R. I. D. T. J. O. F., Olweus, J. O. H. A. N. N. A., Horejsi, V. A. C. L. A. V., Skubitz, K. M., Thompson, J. S., Vilella, R., Symington, F. W. (1992) . Activation of human phagocytes through carbohydrate antigens (CD15, sialyl-CD15, CDw17, and CDw65) .The Journal of Immunology,148 (10), 3221-3229.

• Background Reference 03:

  Schmidt, T., Zndorf, J., Grger, T., Brandenburg, K., Reiners, A. L., Zinserling, J., Schnitzler, N. (2012) . CD66b overexpression and homotypic aggregation of human peripheral blood neutrophils after activation by a gram-positive stimulus.Journal of leukocyte biology,91 (5), 791-802.

• Other Product Names:

  CD67, CGM6, CD66b, NCA-95, CEACAM8

• Tested Applications:

  Flow

• Physical Properties:

  Liquid