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CD44 Antibody [IM7]

CAT: 0223-76-409Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0223-76-409Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24) . CD44 is expressed on hematopoietic and non-hematopoietic cells, bone marrow myeloid cells, memory T lymphocytes, periphery activated B cells, CD4+ T lymphocytes, and CD8+ T lymphocytes. The periphery B and T lymphocytes upregulate the expression of CD44. CD44 binds to hyaluronan molecules, acting as an adhesion molecule.The IM7 antibody inhibits collagen-induced arthritis in DBA/1 mice, prevents central nervous system inflammation associated with experimental autoimmune encephalomyelitis, but exacerbates the experimental autoimmune thyroiditis in CBA/J mice. The IM7 antibody also cross-reacts with dog, human, pig, horse, cat, and cow leukocytes.
NCBI Gene ID
960;12505
Swiss Prot
P16070; P15379
Host
Rat
Reactivity
Human, Mouse
Clonality
Monoclonal
Clone
IM7
Conjugation
Unconjugated
Type
Primary Antibodies, Functional Antibodies
Field of Research
Other
Purification
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C . Do not freeze.
Fragment
Rat IgG2b, kappa
Specificity
The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24) .
Symbol
CD44
NCBI Official Name
CD44 molecule (Indian blood group)
NCBI Organism
Homo sapiens; Mus musculus
Background Reference 01
Trowbridge, I. S., Lesley, J., Schulte, R., Hyman, R., Trotter, J. (1982) . Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues.Immunogenetics,15 (3), 299-312.
Background Reference 02
Lesley, J., Trowbridge, I. S. (1982) . Genetic characterization of a polymorphic murine cell-surface glycoprotein.Immunogenetics,15 (3), 313-320.
Background Reference 03
Nedvetzki, S., Walmsley, M., Alpert, E., Williams, R. O., Feldmann, M., Naor, D. (1999) . CD44 involvement in experimental collagen-induced arthritis (CIA) .Journal of autoimmunity,13 (1), 39-47.
Other Product Names
IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CDW44, CSPG8, HCELL, HUTCH-I, ECMR-III, Ly-24, Pgp-1, HERMES, AU023126, AW121933, AW146109, CD44
Tested Applications
Flow, Functional Assays
Physical Properties
Liquid

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