CD44 Antibody [IM7]

• Background:

  The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24) . CD44 is expressed on hematopoietic and non-hematopoietic cells, bone marrow myeloid cells, memory T lymphocytes, periphery activated B cells, CD4+ T lymphocytes, and CD8+ T lymphocytes. The periphery B and T lymphocytes upregulate the expression of CD44. CD44 binds to hyaluronan molecules, acting as an adhesion molecule.The IM7 antibody inhibits collagen-induced arthritis in DBA/1 mice, prevents central nervous system inflammation associated with experimental autoimmune encephalomyelitis, but exacerbates the experimental autoimmune thyroiditis in CBA/J mice. The IM7 antibody also cross-reacts with dog, human, pig, horse, cat, and cow leukocytes.

• NCBI Gene ID:

  960;12505

• Swiss Prot:

  P16070; P15379

• Host:

  Rat

• Reactivity:

  Human, Mouse

• Clonality:

  Monoclonal

• Clone:

  IM7

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies, Functional Antibodies

• Field of Research:

  Other

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C . Do not freeze.

• Fragment:

  Rat IgG2b, kappa

• Specificity:

  The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24) .

• Symbol:

  CD44

• NCBI Official Name:

  CD44 molecule (Indian blood group)

• NCBI Organism:

  Homo sapiens; Mus musculus

• Background Reference 01:

  Trowbridge, I. S., Lesley, J., Schulte, R., Hyman, R., Trotter, J. (1982) . Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues.Immunogenetics,15 (3), 299-312.

• Background Reference 02:

  Lesley, J., Trowbridge, I. S. (1982) . Genetic characterization of a polymorphic murine cell-surface glycoprotein.Immunogenetics,15 (3), 313-320.

• Background Reference 03:

  Nedvetzki, S., Walmsley, M., Alpert, E., Williams, R. O., Feldmann, M., Naor, D. (1999) . CD44 involvement in experimental collagen-induced arthritis (CIA) .Journal of autoimmunity,13 (1), 39-47.

• Other Product Names:

  IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CDW44, CSPG8, HCELL, HUTCH-I, ECMR-III, Ly-24, Pgp-1, HERMES, AU023126, AW121933, AW146109, CD44

• Tested Applications:

  Flow, Functional Assays

• Physical Properties:

  Liquid