CD61 Antibody [2C9.G3]

• Background:

  The 2C9.G3 monoclonal antibody specifically reacts with the mouse/rat CD61 molecule, known as the integrin beta 3 that forms the vitronectin receptor with CD51. The complex binds to other ligands such as fibrinogen, fibronectin, thrombospondin, and von WIllebrand factor. It is expressed by granulocytes, platelets, activated T cells, smooth muscle, and a subset of B cells.

• NCBI Gene ID:

  16416

• Swiss Prot:

  O54890

• Host:

  Hamster

• Reactivity:

  Mouse, Rat

• Clonality:

  Monoclonal

• Clone:

  2C9.G3

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies, Functional Antibodies

• Field of Research:

  Immunology

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C . Do not freeze.

• Fragment:

  Armenian Hamster IgG

• Specificity:

  The 2C9.G3 monoclonal antibody specifically reacts with the mouse/rat CD61 molecule, known as the integrin beta 3 that forms the vitronectin receptor with CD51.

• Symbol:

  Itgb3

• NCBI Official Name:

  Integrin beta 3

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Vaillant, F., Asselin-Labat, M. L., Shackleton, M., Forrest, N. C., Lindeman, G. J., Visvader, J. E. (2008) . The mammary progenitor marker CD61/-beta 3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis.Cancer research,68 (19), 7711-7717.

• Background Reference 02:

  Yasuda, M., Hasunuma, Y., Adachi, H., Sekine, C., Sakanishi, T., Hashimoto, H., ... Okumura, K. (1995) . Expression and function of fibronectin binding integrins on rat mast cells.International immunology,7 (2), 251-258.

• Background Reference 03:

  Wu, X., Mogford, J. E., Platts, S. H., Davis, G. E., Meininger, G. A., Davis, M. J. (1998) . Modulation of calcium current in arteriolar smooth muscle by alpha v-beta 3 and alpha 5-beta 1 integrin ligands.The Journal of cell biology,143 (1), 241-252.

• Other Product Names:

  CD61, GP3A, INGRB3, Itgb3

• Tested Applications:

  Flow, Functional Assays

• Physical Properties:

  Liquid