CD61 Antibody [VI-PL2]

• Background:

  The VI-PL2 monoclonal antibody reacts with CD61, a type I integral transmembrane glycoprotein also known as integrin beta 3. CD61 forms a complex with CD41 (platelet gpIIb) and CD51 (integrin alphaV) . It is expressed on osteoclasts, fibroblasts, platelets, macrophages, and megakaryocytes and appears to bind to fibronectin, vitronectin, thrombospondin, and fibrinogen and vWF. The VI-PL2 antibody is reported to be cross-reactive with baboon, rhesus, and cynomolgus.

• NCBI Gene ID:

  3690

• Swiss Prot:

  P05106

• Host:

  Mouse

• Reactivity:

  Human

• Clonality:

  Monoclonal

• Clone:

  VI-PL2

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies, Functional Antibodies

• Field of Research:

  Immunology

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C . Do not freeze.

• Fragment:

  Mouse IgG1, kappa

• Specificity:

  The VI-PL2 monoclonal antibody reacts with CD61, a type I integral transmembrane glycoprotein also known as integrin beta 3.

• Symbol:

  ITGB3

• NCBI Official Name:

  Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Leucocyte Typing VI: White Cell Differentiation Antigens: Proceedings of the Sixth International Workshop and Conference Held in Kobe, Japan, 10-14 November 1996. Garland Pub., 1998.

• Background Reference 02:

  Barrett, L., Dai, C., Gamberg, J., Gallant, M., Grant, M. (2007) . Circulating CD14 CD36+ peripheral blood mononuclear cells constitutively produce interleukin-10.Journal of leukocyte biology,82 (1), 152-160.

• Background Reference 03:

  Schlossman, S. F. (1995) .Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.

• Other Product Names:

  GT, CD61, GP3A, BDPLT2, GPIIIa, BDPLT16, ITGB3

• Tested Applications:

  Flow, IHC, Functional Assays, WB

• Physical Properties:

  Liquid