CD31 Antibody [WM59]

• Background:

  The WM59 monoclonal antibody specifically reacts with human CD31, a 130-140 kDA type I transmembrane glycoprotein also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1) or Endocam. CD31 is reported to bind to CD38 and is expressed on platelets, monocytes, granulocytes, and endothelial cells. It plays a role in angiogenesis, wound healing, cellular migration, and signal transduction.

• NCBI Gene ID:

  5175

• Swiss Prot:

  P16284

• Host:

  Mouse

• Reactivity:

  Human

• Clonality:

  Monoclonal

• Clone:

  WM59

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies, Functional Antibodies

• Field of Research:

  Cancer

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C . Do not freeze.

• Fragment:

  Mouse IgG1, kappa

• Specificity:

  The WM59 monoclonal antibody specifically reacts with human CD31, a 130-140 kDA type I transmembrane glycoprotein also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1) or Endocam.

• Symbol:

  PECAM1

• NCBI Official Name:

  Platelet/endothelial cell adhesion molecule 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Schlossman, S. F. (1995) .Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.

• Background Reference 02:

  Porat, Y., Porozov, S., Belkin, D., Shimoni, D., Fisher, Y., Belleli, A., ... Savion, N. (2006) . Isolation of an adult blood‐derived progenitor cell population capable of differentiation into angiogenic, myocardial and neural lineages.British journal of haematology,135 (5), 703-714.

• Background Reference 03:

  Vaporciyan, A. A., DeLisser, H. M., Yan, H. C., Jones, M. L., Ward, P. A., Albelda, S. M. (1993) . Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo.Science,262 (5139), 1580-1582.

• Other Product Names:

  CD31, PECA1, GPIIA', PECAM-1, endoCAM, CD31/EndoCAM, PECAM1

• Tested Applications:

  Flow, Functional Assays

• Physical Properties:

  Liquid