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M CD31 Antibody

CAT: 0223-55-514Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-514Size:400 µL
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Background
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment) . Modulates BDKRB2 activation (By similarity) . Induces susceptibility to atherosclerosis.
NCBI Gene ID
18613
Swiss Prot
Q08481
Accession Number
Q08481
Host
Rabbit
Reactivity
Mouse, Hamster
Immunogen
This Mouse CD31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 508-536 amino acids from the C-terminal region of mouse CD31.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
81 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
Pecam1
NCBI Official Name
Platelet endothelial cell adhesion molecule
NCBI Organism
Mus musculus
Background Reference 01
DeLisser, H., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (43) :18616-18621 (2010)
Background Reference 02
Zhang, C., et al. Dev. Dyn. 239 (10) :2594-2602 (2010)
Background Reference 03
Enciso, J.M., et al. Dev. Dyn. 239 (10) :2570-2583 (2010)
Background Reference 04
Ni, A., et al. Dev. Dyn. 239 (9) :2354-2366 (2010)
Other Product Names
Platelet endothelial cell adhesion molecule, PECAM-1, CD31, Pecam1, Pecam, Pecam-1
Tested Applications
WB
Physical Properties
Liquid

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